In Texas, a two-year clinical trial included 45 performance horses with hock lameness. On a polo farm in Nigeria, 16 lame horses (15 to 22 years of age) were selected for a study on the effects of resveratrol supplementation in aging performance horses. The resveratrol was administered in the form of the oral supplement, Equithrive® Joint (Biological Prospects®LLC).
The Journal of the American Veterinary Medical Association published, “A randomized, controlled trial of the effects of resveratrol administration in performance horses with lameness localized to the distal tarsal joints” in the September 15 issue in 2016. The study results suggested that daily resveratrol administration can reduce hock lameness in performance horses. Specifically, the study determined that in performance horses with lameness localized to the distal tarsal joints, injection of triamcinolone in the centrodistal and tarsometatarsal joints of both hind limbs followed by oral supplementation with resveratrol for 4 months resulted in reduced lameness, compared with triamcinolone injection and supplementation with a placebo.
The research was led by Ashlee E. Watts, DVM, PhD, DACVS, at Texas A&M University. She also presented the results at the December American Association of Equine Practitioners (AAEP) conference, with the following remarks:
“This was a two-year research project and it is very exciting to me because blinded, randomized and controlled clinical trials are not commonly performed in equine veterinary medicine. This type of study is especially rare in the equine supplement industry due to time and cost involved and there are no requirements for understanding the mechanism of action or even for proof of efficacy of supplements marketed in the United States,” said Dr. Watts. “This is in contrast to drugs, which are strictly regulated by the FDA, where companies are required to demonstrate safety and efficacy in client-owned horses with naturally occurring disease prior to approval in the United States.”
To read the research in full, go to http://avmajournals.avma.org/doi/full/10.2460/javma.249.6.570
The April 2016 Journal of Equine Science published “Effects of a joint supplement whose main components are resveratrol and hyaluronic acid on some biochemical parameters in aged lame horses”. The research was conducted by veterinarians in the Department of Veterinary Medicine at Ahmadu Bello University, Zaria, Nigeria. The resveratrol was administered in the form of the oral supplement, Equithrive® Joint (Biological Prospects®LLC).
The researchers reported, “There was a significant reduction in values of creatine kinase and glucose in the horses administered the resveratrol and hyaluronic acid (RH) supplement.” Creatine kinase and glucose are involved in cellular energy metabolism, and elevated levels of these substances have been associated with a reduction in metabolic efficiency in aging animals. The investigators concluded “the RH supplement may reduce the level of these biochemical parameters and their deleterious effects especially during ageing in horses.”
To read the research in full, go to
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