Dr. Frank Reily
Typical IR Horse
Cresty Neck
We now know that the vast majority of laminitis cases are caused by high insulin levels – hyperinsulinemia. Does this mean being overweight/obese causes insulin problems?
It might seem that way superficially but the logic is faulty.
There is an important principle in science which states, “Correlation (or association) is not causation”. Observing that things occur together does not mean one causes the other. Let’s say that the native horses of the country Muropa are observed to regularly consume the leaves of the Bajunga plant, which only grows in Muropa. It has also been observed that Muropa horses never develop sweet itch. Does this mean Bajunga protects from sweet itch? While there could be a link, this doesn’t prove it. It could be a genetic factor protecting them – or simply that there are no Culicoides midges in Muropa!
Many horses that develop laminitis are overweight or obese. We know that the vast majority of laminitis cases are caused by high insulin levels. The correlation has always been obvious and it didn’t take long for an assumption to arise that obesity is a laminitis risk factor and causes elevated insulin. There’s just one thing: It’s not true.
A study (Bamford) published in the Equine Veterinary Journal in 2015, fed horses and ponies a control diet or one designed to cause obesity, by feeding either excess fat or excess fat and glucose. The weight gain did not reduce insulin sensitivity in either group. Dr. Bamford has also clearly shown that insulin responses to oral or intravenous glucose have marked variation by breed in horses of normal weight. You can read all of Dr. Bamford’s work in detail in his thesis here: https://minerva-access.unimelb.edu.au/bitstream/handle/11343/148423/Bamford%20PhD%20Thesis.pdf?sequence=1.
Selim, et al., 2015, followed two groups of Finnhorse mares on either native pasture or intensively managed improved pasture. At the end of 98 days of grazing, the mares on improved pasture went from a body condition score of 5.5 to 7 and gained 145 pounds; but this was not associated with insulin resistance.
If obesity isn’t a cause, why is more insulin resistance seen in obese horses – 25 to 50% IR depending on the study versus 10 to 15% of horses in general? The answer is simple. The IR increases appetite and weight gain. Yes, there is an association between obesity and high insulin but obesity is the result, not the cause.
This is more than just splitting hairs. If you think obesity is a cause, then weight control becomes a treatment — even possibly a cure. When you realize it is a consequence, not a cause, expectations for results of weight loss become more realistic. There are many benefits to weight loss and it should be aggressively pursued, but it won’t make insulin resistance go away. Approximately 50% of IR horses are normal weight.
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About ECIR Group Inc.
Started in 1999, the ECIR Group is the largest field-trial database for PPID and IR in the world and provides the latest research, diagnosis, and treatment information, in addition to dietary recommendations, for horses with these conditions. Even universities do not and cannot compile and follow long term as many in-depth case histories of PPID/IR horses as the ECIR Group.
In 2013 the Equine Cushing's and Insulin Resistance Group Inc., an Arizona nonprofit corporation, was approved as a 501(c)3 public charity. Tax-deductible contributions and grants support ongoing research, education, and awareness of Equine Cushing's Disease/PPID and Insulin Resistance.
THE MISSION of the ECIR Group Inc. is to improve the welfare of equines with metabolic disorders via a unique interface between basic research, and real-life clinical experience. Prevention of laminitis is the ultimate goal. The ECIR Group serves the scientific community, practicing clinicians, and owners by focusing on investigations most likely to quickly, immediately, and significantly benefit the welfare of the horse.